This course analyzes state, federal, and international laws governing psychedelic substances such as psilocybin, mescaline, ibogaine, and dimethyltryptamine (DMT). The course may be of interest to students of many legal disciplines, including health law, criminal law, FDA regulation, constitutional law, religious freedom, and business law. The topics covered include the regulation of psychedelic substance possession, production, sales, research, and use in the contexts of healthcare, commerce, spirituality, and Indigenous traditions. Students will learn about psychedelic laws of the Global North and South and the roles of international treaties, the First Amendment, state and federal agencies, and local, state, and national drug policy reforms. Students will produce a substantial research paper on their topic of choice related to the course material.